This family of proteins is functionally uncharacterised. This family of proteins is found in eukaryotes. Proteins in this family are typically between 288 and 410 amino acids in length. There are two completely conserved C residues that may be functionally important. In mammals this protein family is thyroid-specific [[cite:PUB00076024]].
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":{"PUB00076024":{"PMID":20578903,"ISBN":null,"volume":"20","issue":"7","year":2010,"title":"Initial characterization of C16orf89, a novel thyroid-specific gene.","URL":null,"raw_pages":"811-21","medline_journal":"Thyroid","ISO_journal":"Thyroid","authors":["Afink GB","Veenboer G","de Randamie J","Keijser R","Meischl C","Niessen H","Ris-Stalpers C."],"DOI_URL":"http://dx.doi.org/10.1089/thy.2009.0366"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":29,"interactions":0,"matches":1461,"pathways":0,"proteins":1382,"proteomes":782,"sets":0,"structural_models":{"alphafold":1150},"structures":0,"taxa":2727},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":24,"alignment:full":1004},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}