{"metadata":{"accession":"PF15854","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR031713","hierarchy":null,"name":{"name":"G-protein coupled receptor ligand 15","short":"GPR15L"},"description":[{"text":"<p>GPR15 is an orphan G protein-coupled receptor (GPCR) that is found in lymphocytes. It functions as a co-receptor of simian immunodeficiency virus and HIV-2 and plays a role in the trafficking of T cells to the lamina propria in the colon and to the skin [[cite:PUB00088053]]. An activating ligand named GPR15L is shown to bind GPR15 and attract GPR15-expressing T cells including lymphocytes in colon-draining lymph nodes and thymic precursors of dermal epithelial T cell. This 9kDa CC-motif containing cationic polypeptide has been previously described as the 57 amino acid antimicrobial peptide AP-57, and as a Sushi Containing Domain-2 (SUSD2)-binding factor (CSBF), capable of inhibiting the growth of intestinal epithelial cancer cell lines. The chemokine is expressed by epithelial cells in gastrointestinal and genitourinary mucosae and in the skin [[cite:PUB00088054]]. In humans GPR15L, is encoded by the gene C10ORF99 and has some features similar to the CC family of chemokines [[cite:PUB00088053]]. However, it lacks significant homology to classic CC and CXC chemokines, yet shares many features with them, including a cationic domain predicted to comprise two disulfide bonds and a highly conserved GPCR-activating terminal peptide. Furthermore, the activating peptides of CC chemokines are typically located at the N-terminus, while that of GPR15L is C-terminal, a feature that it shares with some other GPCR ligands like chemerin and apela [[cite:PUB00088054]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00088053":{"PMID":28900043,"ISBN":null,"volume":"10","issue":"496","year":2017,"title":"A natural ligand for the orphan receptor GPR15 modulates lymphocyte recruitment to epithelia.","URL":null,"raw_pages":null,"medline_journal":"Sci Signal","ISO_journal":"Sci Signal","authors":["Suply T","Hannedouche S","Carte N","Li J","Grosshans B","Schaefer M","Raad L","Beck V","Vidal S","Hiou-Feige A","Beluch N","Barbieri S","Wirsching J","Lageyre N","Hillger F","Debon C","Dawson J","Smith P","Lannoy V","Detheux M","Bitsch F","Falchetto R","Bouwmeester T","Porter J","Baumgarten B","Mansfield K","Carballido JM","Seuwen K","Bassilana F."],"DOI_URL":"https://doi.org/10.1126/scisignal.aal0180"},"PUB00088054":{"PMID":28936214,"ISBN":null,"volume":"8","issue":null,"year":2017,"title":"A Mucosal and Cutaneous Chemokine Ligand for the Lymphocyte Chemoattractant Receptor GPR15.","URL":null,"raw_pages":"1111","medline_journal":"Front Immunol","ISO_journal":"Front Immunol","authors":["Ocon B","Pan J","Dinh TT","Chen W","Ballet R","Bscheider M","Habtezion A","Tu H","Zabel BA","Butcher EC."],"DOI_URL":"https://doi.org/10.3389/fimmu.2017.01111"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":4,"interactions":0,"matches":122,"pathways":0,"proteins":121,"proteomes":114,"sets":0,"structural_models":{"alphafold":106},"structures":1,"taxa":422},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":6,"alignment:full":106},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}