{"metadata":{"accession":"PF15771","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR031529","hierarchy":null,"name":{"name":"Interactor of HORMAD1 protein 1","short":"IHO1"},"description":[{"text":"<p>Interactor of HORMAD1 protein 1 (IHO1, previously known as coiled-coil domain-containing protein 36 or DUF4700) is required for DNA double-strand breaks (DSBs) formation in unsynapsed regions during meiotic recombination. It is thought to function, in collaboration with SPO11-auxiliary proteins MEI4 and REC114, through the formation of DSB-promoting recombinosomes on chromatin at the onset of meiosis [[cite:PUB00083216]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00083216":{"PMID":27723721,"ISBN":null,"volume":"18","issue":"11","year":2016,"title":"Meiotic DNA break formation requires the unsynapsed chromosome axis-binding protein IHO1 (CCDC36) in mice.","URL":null,"raw_pages":"1208-1220","medline_journal":"Nat Cell Biol","ISO_journal":"Nat. Cell Biol.","authors":["Stanzione M","Baumann M","Papanikos F","Dereli I","Lange J","Ramlal A","Trankner D","Shibuya H","de Massy B","Watanabe Y","Jasin M","Keeney S","Toth A."],"DOI_URL":"http://dx.doi.org/10.1038/ncb3417"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":6,"interactions":0,"matches":748,"pathways":0,"proteins":713,"proteomes":630,"sets":0,"structural_models":{"alphafold":652},"structures":0,"taxa":1947},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":14,"alignment:full":653},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}