{"metadata":{"accession":"PF15749","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR049472","hierarchy":null,"name":{"name":"MRN-interacting protein","short":"MRNIP"},"description":[{"text":"<p>This family is found in eukaryotes. Family members include MRN complex-interacting protein (MRNIP), which plays a role in preventing the accumulation of damaged DNA in cells. It associates with the MRE11-RAD50-NBS1 (MRN) damage-sensing complex and is rapidly recruited to sites of DNA damage. Phosphorylation of a serine promotes nuclear localization of MRNIP [[cite:PUB00083234]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00083234":{"PMID":27568553,"ISBN":null,"volume":"16","issue":"10","year":2016,"title":"MRNIP/C5orf45 Interacts with the MRN Complex and Contributes to the DNA Damage Response.","URL":null,"raw_pages":"2565-75","medline_journal":"Cell Rep","ISO_journal":"Cell Rep","authors":["Staples CJ","Barone G","Myers KN","Ganesh A","Gibbs-Seymour I","Patil AA","Beveridge RD","Daye C","Beniston R","Maslen S","Ahel I","Skehel JM","Collis SJ."],"DOI_URL":"http://dx.doi.org/10.1016/j.celrep.2016.07.087"}},"set_info":{"accession":"CL0167","name":"Zn_Beta_Ribbon"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":27,"interactions":0,"matches":1591,"pathways":0,"proteins":1583,"proteomes":1219,"sets":1,"structural_models":{"alphafold":1370},"structures":0,"taxa":4007},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":23,"alignment:full":1190},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}