{"metadata":{"accession":"PF15636","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR028916","hierarchy":null,"name":{"name":"GHH signature containing HNH/Endo VII superfamily nuclease toxin","short":"Tox-GHH"},"description":[{"text":"<p>A predicted toxin of the HNH/Endonuclease VII fold present in bacterial polymorphic toxin systems with a characteristic sG[HQ]H signature motif. In bacterial polymorphic toxin systems, the toxin is exported by the type 2, type 6, type 7 or TcdB/TcaC-type secretion system. The metazoan teneurin proteins possess an inactive  of this domain at their C-terminus [[cite:PUB00066726]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00066726":{"PMID":22731697,"ISBN":null,"volume":"7","issue":null,"year":2012,"title":"Polymorphic toxin systems: Comprehensive characterization of trafficking modes, processing, mechanisms of action, immunity and ecology using comparative genomics.","URL":null,"raw_pages":"18","medline_journal":"Biol Direct","ISO_journal":"Biol. Direct","authors":["Zhang D","de Souza RF","Anantharaman V","Iyer LM","Aravind L."],"DOI_URL":"http://dx.doi.org/10.1186/1745-6150-7-18"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":210,"interactions":0,"matches":9377,"pathways":0,"proteins":9375,"proteomes":1237,"sets":0,"structural_models":{"alphafold":468,"bfvd":0},"structures":13,"taxa":4278},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":25,"alignment:full":6352},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}