{"metadata":{"accession":"PF15395","entry_id":null,"type":"disordered","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR027866","hierarchy":null,"name":{"name":"Retroelement silencing factor 1 C-terminal region","short":"RESF1_C"},"description":[{"text":"<p>This entry represents the C-terminal region of approximately 1000 residues found in retroelement silencing factor 1 (RESF1) proteins in vertebrates. The full-length RESF1 protein interacts with the histone methyltransferase SETDB1 and is required for the recruitment of SETDB1 to endogenous retroviruses (ERVs), contributing to ERV silencing in embryonic stem cells [[cite:PUB00092441]]. The specific function of this C-terminal region remains to be determined.</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00092441":{"PMID":29728365,"ISBN":null,"volume":"28","issue":"6","year":2018,"title":"A CRISPR knockout screen identifies SETDB1-target retroelement silencing factors in embryonic stem cells.","URL":null,"raw_pages":"846-858","medline_journal":"Genome Res","ISO_journal":"Genome Res.","authors":["Fukuda K","Okuda A","Yusa K","Shinkai Y."],"DOI_URL":"https://doi.org/10.1101/gr.227280.117"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":8,"interactions":0,"matches":514,"pathways":0,"proteins":453,"proteomes":284,"sets":0,"structural_models":{"alphafold":20},"structures":0,"taxa":954},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":47,"alignment:full":433},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}