{"metadata":{"accession":"PF15384","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR027873","hierarchy":null,"name":{"name":"PAXX, PAralog of XRCC4 and XLF, also called C9orf142","short":"PAXX"},"description":[{"text":"<p>PAXX is a set of eukaryotic proteins that belong to the XRCC4 superfamily of DNA-double-strand break-repair proteins. PAXX interacts directly with DSB-repair protein Ku and is recruited to DNA-damage sites in cells thus functioning with XRCC4 and XLF to bring about DSB repair and cell survival in response to DSB-inducing agents [[cite:PUB00074304]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00074304":{"PMID":25574025,"ISBN":null,"volume":"347","issue":"6218","year":2015,"title":"DNA repair. PAXX, a paralog of XRCC4 and XLF, interacts with Ku to promote DNA double-strand break repair.","URL":null,"raw_pages":"185-8","medline_journal":"Science","ISO_journal":"Science","authors":["Ochi T","Blackford AN","Coates J","Jhujh S","Mehmood S","Tamura N","Travers J","Wu Q","Draviam VM","Robinson CV","Blundell TL","Jackson SP."],"DOI_URL":"http://dx.doi.org/10.1126/science.1261971"}},"set_info":{"accession":"CL0777","name":"XRCC4_N"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":7,"interactions":0,"matches":777,"pathways":0,"proteins":757,"proteomes":553,"sets":1,"structural_models":{"alphafold":650},"structures":20,"taxa":1971},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":8,"alignment:full":615},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}