{"metadata":{"accession":"PF15373","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR028001","hierarchy":null,"name":{"name":"Stabilizer of axonemal microtubules 5","short":"SAXO5-like"},"description":[{"text":"<p>This family (previously DUF4601) represents the homologues of Stabilizer of axonemal microtubules 5 (SAXO5, also known as C19orf45, TEX45). SAXO5 is a filamentous SAXO protein that binds along protofilament A04 with 96-nm periodicity [[cite:PUB00151496]]. A typical feature of SAXO proteins is the presence of Mn motif which forms a 5- to 6-residue helix flanked by a Tyr/Phe residue on one end and by a Ser/Thr on the other that binds the shoulder of the alpha-tubulin S9/S10 loop [[cite:PUB00151502]]. SAXO5 contains 11 Mn motifs and therefore has 96-nm periodicity, matching the external periodicity of the axoneme [[cite:PUB00151496]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00151502":{"PMID":34031406,"ISBN":null,"volume":"12","issue":"1","year":2021,"title":"Cryo-EM structure of cortical microtubules from human parasite Toxoplasma gondii identifies their microtubule inner proteins.","URL":null,"raw_pages":"3065","medline_journal":"Nat Commun","ISO_journal":"Nat Commun","authors":["Wang X","Fu Y","Beatty WL","Ma M","Brown A","Sibley LD","Zhang R."],"DOI_URL":"https://doi.org/10.1038/s41467-021-23351-1"},"PUB00151496":{"PMID":37327785,"ISBN":null,"volume":"186","issue":"13","year":2023,"title":"Structural specializations of the sperm tail.","URL":null,"raw_pages":"2880-2896.e17","medline_journal":"Cell","ISO_journal":"Cell","authors":["Leung MR","Zeng J","Wang X","Roelofs MC","Huang W","Zenezini Chiozzi R","Hevler JF","Heck AJR","Dutcher SK","Brown A","Zhang R","Zeev-Ben-Mordehai T."],"DOI_URL":"https://doi.org/10.1016/j.cell.2023.05.026"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":9,"interactions":0,"matches":447,"pathways":0,"proteins":425,"proteomes":338,"sets":0,"structural_models":{"alphafold":349},"structures":0,"taxa":1187},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":8,"alignment:full":352},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}