{"metadata":{"accession":"PF15363","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR027907","hierarchy":null,"name":{"name":"BTB/POZ domain-containing protein 8, C-terminal","short":"BTBD8_C"},"description":[{"text":"<p>This domain is found at the C terminus of BTB/POZ domain-containing protein 8 (BTBD8, also known as AP2-interacting clathrin-endocytosis protein). BTBD8  is involved in clathrin-mediated endocytosis at the synapse and plays a role in neuronal development and in synaptic vesicle recycling in mature neurons, a process required for normal synaptic transmission [[cite:PUB00090548]]. There is a conserved ELET sequence motif. There are two completely conserved residues (S and E) that may be functionally important.</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00090548":{"PMID":29262337,"ISBN":null,"volume":"21","issue":"12","year":2017,"title":"APache Is an AP2-Interacting Protein Involved in Synaptic Vesicle Trafficking and Neuronal Development.","URL":null,"raw_pages":"3596-3611","medline_journal":"Cell Rep","ISO_journal":"Cell Rep","authors":["Piccini A","Castroflorio E","Valente P","Guarnieri FC","Aprile D","Michetti C","Bramini M","Giansante G","Pinto B","Savardi A","Cesca F","Bachi A","Cattaneo A","Wren JD","Fassio A","Valtorta F","Benfenati F","Giovedi S."],"DOI_URL":"https://doi.org/10.1016/j.celrep.2017.11.073"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":14,"interactions":0,"matches":1304,"pathways":0,"proteins":1304,"proteomes":654,"sets":0,"structural_models":{"alphafold":302},"structures":0,"taxa":2031},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":7,"alignment:full":1020},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}