{"metadata":{"accession":"PF15251","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR029196","hierarchy":null,"name":{"name":"Telomere attrition and p53 response 1 protein-like","short":"TAPR1-like"},"description":[{"text":"<p>This entry represents the Telomere attrition and p53 response 1 protein (TAPR1) from eukaryotes, including TAPR1 from human (also known as C16orf72/HAPSTR1), which is a multistress-responsive protein that functions as a negative regulator of TP53/P53 in the cellular response to telomere erosion and probably also DNA damage. It may attenuate p53/TP53 activation through the E3 ubiquitin ligase HUWE1 which also promotes TAPR1's degradation [[cite:PUB00100199],[cite:PUB00101217]]. This family also includes uncharacterised proteins from fungi, such as YJR056C from yeast.</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00101217":{"PMID":35776542,"ISBN":null,"volume":"119","issue":"27","year":2022,"title":"C16orf72/HAPSTR1 is a molecular rheostat in an integrated network of stress response pathways.","URL":null,"raw_pages":"e2111262119","medline_journal":"Proc Natl Acad Sci U S A","ISO_journal":"Proc Natl Acad Sci U S A","authors":["Amici DR","Ansel DJ","Metz KA","Smith RS","Phoumyvong CM","Gayatri S","Chamera T","Edwards SL","O'Hara BP","Srivastava S","Brockway S","Takagishi SR","Cho BK","Goo YA","Kelleher NL","Ben-Sahra I","Foltz DR","Li J","Mendillo ML."],"DOI_URL":null},"PUB00100199":{"PMID":33660365,"ISBN":null,"volume":"20","issue":"4","year":2021,"title":"A novel p53 regulator, C16ORF72/TAPR1, buffers against telomerase inhibition.","URL":null,"raw_pages":"e13331","medline_journal":"Aging Cell","ISO_journal":"Aging Cell","authors":["Benslimane Y","Sanchez-Osuna M","Coulombe-Huntington J","Bertomeu T","Henry D","Huard C","Bonneil E","Thibault P","Tyers M","Harrington L."],"DOI_URL":null}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":20,"interactions":0,"matches":2580,"pathways":0,"proteins":2553,"proteomes":1830,"sets":0,"structural_models":{"alphafold":2173},"structures":0,"taxa":5222},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":9,"alignment:full":1928},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}