{"metadata":{"accession":"PF15162","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR027857","hierarchy":null,"name":{"name":"Protein SPO16 homolog","short":"SCRE"},"description":[{"text":"<p>This entry represents the Protein SPO16 homolog (SPO16, also known as Synaptonemal complex reinforcing element SCRE), including the mammalian orthologue of budding yeast Spo16. It plays a key role in reinforcing the integrity of the central element of the synaptonemal complex (SC), resulting in the SC stabilization which ensures the progression of meiotic prophase I in male and female germ cells [1. It promotes homologous recombination and crossing-over in meiotic prophase I via its association with SHOC1 [[cite:PUB00096701]]. It is also required for the localization of TEX11 and MSH4 to recombination intermediates [[cite:PUB00096701]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00096701":{"PMID":30746471,"ISBN":null,"volume":"5","issue":"1","year":2019,"title":"SPO16 binds SHOC1 to promote homologous recombination and crossing-over in meiotic prophase I.","URL":null,"raw_pages":"eaau9780","medline_journal":"Sci Adv","ISO_journal":"Sci Adv","authors":["Zhang Q","Ji SY","Busayavalasa K","Yu C."],"DOI_URL":null},"PUB00096702":{"PMID":30949703,"ISBN":null,"volume":"47","issue":"11","year":2019,"title":"SCRE serves as a unique synaptonemal complex fastener and is essential for progression of meiosis prophase I in mice.","URL":null,"raw_pages":"5670-5683","medline_journal":"Nucleic Acids Res","ISO_journal":"Nucleic Acids Res","authors":["Liu H","Huang T","Li M","Li M","Zhang C","Jiang J","Yu X","Yin Y","Zhang F","Lu G","Luo MC","Zhang LR","Li J","Liu K","Chen ZJ."],"DOI_URL":null}},"set_info":{"accession":"CL0236","name":"PDDEXK"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":5,"interactions":0,"matches":558,"pathways":0,"proteins":556,"proteomes":477,"sets":1,"structural_models":{"alphafold":485},"structures":0,"taxa":1717},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":10,"alignment:full":444},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}