{"metadata":{"accession":"PF15158","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR027861","hierarchy":null,"name":{"name":"Cation channel sperm-associated auxiliary subunit TMEM249","short":"TMEM249"},"description":[{"text":"<p>This family of proteins is found in eukaryotes and includes Cation channel sperm-associated auxiliary subunit TMEM249 from human (also known as C8orfK29). It is an auxiliary component of the CatSper complex, a complex involved in sperm cell hyperactivation [[cite:PUB00100197]]. TMEM249 contributes to the assembly of the CatSpermasome.</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00100197":{"PMID":34225353,"ISBN":null,"volume":"595","issue":"7869","year":2021,"title":"Structure of a mammalian sperm cation channel complex.","URL":null,"raw_pages":"746-750","medline_journal":"Nature","ISO_journal":"Nature","authors":["Lin S","Ke M","Zhang Y","Yan Z","Wu J."],"DOI_URL":null}},"set_info":{"accession":"CL0266","name":"PH"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":13,"interactions":0,"matches":289,"pathways":0,"proteins":281,"proteomes":243,"sets":1,"structural_models":{"alphafold":232},"structures":3,"taxa":946},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":6,"alignment:full":243},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}