{"metadata":{"accession":"PF15127","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR027969","hierarchy":null,"name":{"name":"Small membrane A-kinase anchor protein","short":"SmAKAP"},"description":[{"text":"<p>SmAKAP is a small membrane-bound PKA-RI-specific protein kinase A-anchoring protein, referred to as small membrane-AKAP. It is probably tethered to the plasma membrane most through a dual acylation of its N-terminal Met-Gly-Cys- motif (myristoylation and palmitoylation, respectively). It specifically targets PKA-RI isoforms to the plasma membrane. It localizes to plasma membranes, is enriched at cell-cell junctions and associates with filopodia [[cite:PUB00067440]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00067440":{"PMID":23115245,"ISBN":null,"volume":"287","issue":"52","year":2012,"title":"A small novel A-kinase anchoring protein (AKAP) that localizes specifically protein kinase A-regulatory subunit I (PKA-RI) to the plasma membrane.","URL":null,"raw_pages":"43789-97","medline_journal":"J Biol Chem","ISO_journal":"J. Biol. Chem.","authors":["Burgers PP","Ma Y","Margarucci L","Mackey M","van der Heyden MA","Ellisman M","Scholten A","Taylor SS","Heck AJ."],"DOI_URL":"http://dx.doi.org/10.1074/jbc.M112.395970"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":1,"interactions":0,"matches":678,"pathways":0,"proteins":678,"proteomes":631,"sets":0,"structural_models":{"alphafold":628},"structures":1,"taxa":1983},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":13,"alignment:full":581},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":{"accession":"5hvz","name":"Crystal structure of smAKAP AKB domain bound RIa dimerization/docking (D/D) complex at 2.0 A resolution"}}}