{"metadata":{"accession":"PF15089","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR027883","hierarchy":null,"name":{"name":"Regulator of DNA class I crossover intermediates 1-like","short":"Redic1-like"},"description":[{"text":"<p>This family of proteins mainly found in vertebrates includes mouse Regulator of DNA class I crossover intermediates 1 (Redic1). Redic1 is involved in recombination, probably acting by stabilising recombination intermediates during meiotic crossover formation. It is required for normal germline development and fertility as well as for meiotic progression, complete chromosomal synapsis and crossover formation [[cite:PUB00153152],[cite:PUB00153151]]. This protein binds double-stranded DNA [[cite:PUB00153152]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00153152":{"PMID":37612290,"ISBN":null,"volume":"9","issue":"1","year":2023,"title":"A novel recombination protein C12ORF40/REDIC1 is required for meiotic crossover formation.","URL":null,"raw_pages":"88","medline_journal":"Cell Discov","ISO_journal":"Cell Discov","authors":["Fan S","Wang Y","Jiang H","Jiang X","Zhou J","Jiao Y","Ye J","Xu Z","Wang Y","Xie X","Zhang H","Li Y","Liu W","Zhang X","Ma H","Shi B","Zhang Y","Zubair M","Shah W","Xu Z","Xu B","Shi Q."],"DOI_URL":"https://doi.org/10.1038/s41421-023-00577-5"},"PUB00153151":{"PMID":37604834,"ISBN":null,"volume":"9","issue":"1","year":2023,"title":"Loss-of-function variants in human C12orf40 cause male infertility by blocking meiotic progression.","URL":null,"raw_pages":"87","medline_journal":"Cell Discov","ISO_journal":"Cell Discov","authors":["Tu C","Wen J","Wang W","Zhu Q","Chen Y","Cheng J","Li Z","Meng L","Li Y","He W","Tan C","Xie C","Fu SM","Du J","Lu G","Lin G","Gou LT","Tan YQ."],"DOI_URL":"https://doi.org/10.1038/s41421-023-00580-w"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":3,"interactions":0,"matches":234,"pathways":0,"proteins":218,"proteomes":157,"sets":0,"structural_models":{"alphafold":167},"structures":0,"taxa":574},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":7,"alignment:full":195},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}