{"metadata":{"accession":"PF15077","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR027816","hierarchy":null,"name":{"name":"Membrane-anchored junction protein","short":"MAJIN"},"description":[{"text":"<p>Membrane-anchored junction protein (MAJIN) is a meiosis-specific telomere-associated protein involved  in meiotic telomere attachment to the nucleus inner  membrane, a crucial step for homologous pairing  and synapsis. It is a component of the MAJIN-TERB1-TERB2  complex, which promotes telomere cap exchange by mediating  attachment of telomeric DNA to the inner nuclear membrane  and replacement of the protective cap of telomeric chromosomes [[cite:PUB00077546]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00077546":{"PMID":26548954,"ISBN":null,"volume":"163","issue":"5","year":2015,"title":"MAJIN Links Telomeric DNA to the Nuclear Membrane by Exchanging Telomere Cap.","URL":null,"raw_pages":"1252-66","medline_journal":"Cell","ISO_journal":"Cell","authors":["Shibuya H","Hernandez-Hernandez A","Morimoto A","Negishi L","Hoog C","Watanabe Y."],"DOI_URL":"http://dx.doi.org/10.1016/j.cell.2015.10.030"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":11,"interactions":0,"matches":668,"pathways":0,"proteins":583,"proteomes":394,"sets":0,"structural_models":{"alphafold":499},"structures":3,"taxa":1419},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":6,"alignment:full":564},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":{"accession":"6gny","name":"Crystal structure of the MAJIN-TERB2 heterotetrameric complex"}}}