{"metadata":{"accession":"PF15075","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR028027","hierarchy":null,"name":{"name":"Sperm microtubule associated protein 1","short":"SPMAP1-like"},"description":[{"text":"<p>This family (previously DUF4542) represents the homologs of Sperm microtubule associated protein 1 (SPMAP1 also known as C17orf98). These proteins contain a conserved IPPYN sequence motif. The EM structure of sperm DMTs shows that SPMAP1 interacts directly with the tubulin lattice at the A-tubule seam (between protofilaments A09/A10) where outer dense fibers (ODFs) are connected to dynein-decorated doublet microtubules (DMTs) [[cite:PUB00151496]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00151496":{"PMID":37327785,"ISBN":null,"volume":"186","issue":"13","year":2023,"title":"Structural specializations of the sperm tail.","URL":null,"raw_pages":"2880-2896.e17","medline_journal":"Cell","ISO_journal":"Cell","authors":["Leung MR","Zeng J","Wang X","Roelofs MC","Huang W","Zenezini Chiozzi R","Hevler JF","Heck AJR","Dutcher SK","Brown A","Zhang R","Zeev-Ben-Mordehai T."],"DOI_URL":"https://doi.org/10.1016/j.cell.2023.05.026"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":13,"interactions":0,"matches":423,"pathways":0,"proteins":404,"proteomes":319,"sets":0,"structural_models":{"alphafold":357},"structures":2,"taxa":1159},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":11,"alignment:full":346},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}