{"metadata":{"accession":"PF15074","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR027901","hierarchy":null,"name":{"name":"Cilia and flagella associated protein 90","short":"CFAP90"},"description":[{"text":"<p>This family represents the homologues of Cilia and flagella associated protein 90 (CFAP90, also known as C5orf49). CFAP90 is a microtubule inner protein (MIP) part of the doublet microtubules (DMTs) in cilia and sperm axoneme [[cite:PUB00103594],[cite:PUB00151496]]. It belongs to the core-MIPs and binds to protofilament B09 in the sperm DMTs. Members of this family contain a conserved KLHRDDR sequence motif.</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00103594":{"PMID":36191189,"ISBN":null,"volume":"119","issue":"41","year":2022,"title":"SPACA9 is a lumenal protein of human ciliary singlet and doublet microtubules.","URL":null,"raw_pages":"e2207605119","medline_journal":"Proc Natl Acad Sci U S A","ISO_journal":"Proc Natl Acad Sci U S A","authors":["Gui M","Croft JT","Zabeo D","Acharya V","Kollman JM","Burgoyne T","Hoog JL","Brown A."],"DOI_URL":null},"PUB00151496":{"PMID":37327785,"ISBN":null,"volume":"186","issue":"13","year":2023,"title":"Structural specializations of the sperm tail.","URL":null,"raw_pages":"2880-2896.e17","medline_journal":"Cell","ISO_journal":"Cell","authors":["Leung MR","Zeng J","Wang X","Roelofs MC","Huang W","Zenezini Chiozzi R","Hevler JF","Heck AJR","Dutcher SK","Brown A","Zhang R","Zeev-Ben-Mordehai T."],"DOI_URL":"https://doi.org/10.1016/j.cell.2023.05.026"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":13,"interactions":0,"matches":745,"pathways":0,"proteins":741,"proteomes":616,"sets":0,"structural_models":{"alphafold":624},"structures":8,"taxa":2233},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":19,"alignment:full":543},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}