{"metadata":{"accession":"PF15061","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR027917","hierarchy":null,"name":{"name":"MITRAC7/Phoenixin family","short":"MITRAC7_Phoenixin"},"description":[{"text":"<p>This entry represents the Small Integral Membrane Protein 20/Phoenixin family, which contains proteins with dual functions. The full-length protein (SMIM20/MITRAC7) is a mitochondrial inner membrane protein that acts as a component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase) complex, regulating cytochrome c oxidase assembly. It functions as a chaperone-like assembly factor required to stabilize newly synthesized MT-CO1/COX1 and prevent its premature turnover. The C-terminal region of this protein is also processed to produce bioactive peptides known as phoenixin-14 and phoenixin-20, which were first identified through a bioinformatic approach. These secreted peptides are involved in multiple physiological functions. They act as ligands for the G protein-coupled receptor GPR173. Phoenixin peptides regulate gonadotropin-releasing hormone (GnRH) signaling in the hypothalamus and pituitary, augmenting luteinizing hormone release. They delay the appearance of estrus when reduced in vivo and modulate GnRH receptor expression. Additionally, phoenixin peptides regulate vasopressin secretion by hypothalamic neurons and have roles in memory retention, anxiety reduction, food intake regulation, granulosa cell proliferation, heart function, and islet cell proliferation.</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00086676":{"PMID":26321642,"ISBN":null,"volume":"12","issue":"10","year":2015,"title":"MITRAC7 Acts as a COX1-Specific Chaperone and Reveals a Checkpoint during Cytochrome c Oxidase Assembly.","URL":null,"raw_pages":"1644-55","medline_journal":"Cell Rep","ISO_journal":"Cell Rep","authors":["Dennerlein S","Oeljeklaus S","Jans D","Hellwig C","Bareth B","Jakobs S","Deckers M","Warscheid B","Rehling P."],"DOI_URL":"https://doi.org/10.1016/j.celrep.2015.08.009"},"PUB00161346":{"PMID":22963497,"ISBN":null,"volume":"25","issue":"2","year":2013,"title":"A novel reproductive peptide, phoenixin.","URL":null,"raw_pages":"206-15","medline_journal":"J Neuroendocrinol","ISO_journal":"J Neuroendocrinol","authors":["Yosten GL","Lyu RM","Hsueh AJ","Avsian-Kretchmer O","Chang JK","Tullock CW","Dun SL","Dun N","Samson WK."],"DOI_URL":"https://doi.org/10.1111/j.1365-2826.2012.02381.x"},"PUB00161347":{"PMID":27440717,"ISBN":null,"volume":"311","issue":"3","year":2016,"title":"Hypothalamic action of phoenixin to control reproductive hormone secretion in females: importance of the orphan G protein-coupled receptor Gpr173.","URL":null,"raw_pages":"R489-96","medline_journal":"Am J Physiol Regul Integr Comp Physiol","ISO_journal":"Am J Physiol Regul Integr Comp Physiol","authors":["Stein LM","Tullock CW","Mathews SK","Garcia-Galiano D","Elias CF","Samson WK","Yosten GL."],"DOI_URL":"https://doi.org/10.1152/ajpregu.00191.2016"},"PUB00161340":{"PMID":25687846,"ISBN":null,"volume":"286","issue":null,"year":2015,"title":"Effects of Phoenixin-14 on anxiolytic-like behavior in mice.","URL":null,"raw_pages":"39-48","medline_journal":"Behav Brain Res","ISO_journal":"Behav Brain Res","authors":["Jiang JH","He Z","Peng YL","Jin WD","Mu J","Xue HX","Wang Z","Chang M","Wang R."],"DOI_URL":"https://doi.org/10.1016/j.bbr.2015.02.011"},"PUB00161342":{"PMID":26415767,"ISBN":null,"volume":"310","issue":null,"year":2015,"title":"Phoenixin: A candidate pruritogen in the mouse.","URL":null,"raw_pages":"541-8","medline_journal":"Neuroscience","ISO_journal":"Neuroscience","authors":["Cowan A","Lyu RM","Chen YH","Dun SL","Chang JK","Dun NJ."],"DOI_URL":"https://doi.org/10.1016/j.neuroscience.2015.09.055"},"PUB00161341":{"PMID":26505917,"ISBN":null,"volume":"1629","issue":null,"year":2015,"title":"Phoenixin-14 enhances memory and mitigates memory impairment induced by Aβ1-42 and scopolamine in mice.","URL":null,"raw_pages":"298-308","medline_journal":"Brain Res","ISO_journal":"Brain Res","authors":["Jiang JH","He Z","Peng YL","Jin WD","Wang Z","Mu LY","Chang M","Wang R."],"DOI_URL":"https://doi.org/10.1016/j.brainres.2015.10.030"},"PUB00161344":{"PMID":31422055,"ISBN":null,"volume":"1866","issue":"12","year":2019,"title":"Phoenixin-14 stimulates proliferation and insulin secretion in insulin producing INS-1E cells.","URL":null,"raw_pages":"118533","medline_journal":"Biochim Biophys Acta Mol Cell Res","ISO_journal":"Biochim Biophys Acta Mol Cell Res","authors":["Billert M","Kolodziejski PA","Strowski MZ","Nowak KW","Skrzypski M."],"DOI_URL":"https://doi.org/10.1016/j.bbamcr.2019.118533"},"PUB00161343":{"PMID":27268078,"ISBN":null,"volume":"30","issue":"8","year":2016,"title":"Phoenixin Activates Immortalized GnRH and Kisspeptin Neurons Through the Novel Receptor GPR173.","URL":null,"raw_pages":"872-88","medline_journal":"Mol Endocrinol","ISO_journal":"Mol Endocrinol","authors":["Treen AK","Luo V","Belsham DD."],"DOI_URL":"https://doi.org/10.1210/me.2016-1039"},"PUB00161345":{"PMID":30933929,"ISBN":null,"volume":"158","issue":"1","year":2019,"title":"Effect of the neuropeptide phoenixin and its receptor GPR173 during folliculogenesis.","URL":null,"raw_pages":"25-34","medline_journal":"Reproduction","ISO_journal":"Reproduction","authors":["Nguyen XP","Nakamura T","Osuka S","Bayasula B","Nakanishi N","Kasahara Y","Muraoka A","Hayashi S","Nagai T","Murase T","Goto M","Iwase A","Kikkawa F."],"DOI_URL":"https://doi.org/10.1530/REP-19-0025"},"PUB00161349":{"PMID":29364701,"ISBN":null,"volume":"314","issue":"4","year":2018,"title":"Novel regulator of vasopressin secretion: phoenixin.","URL":null,"raw_pages":"R623-R628","medline_journal":"Am J Physiol Regul Integr Comp Physiol","ISO_journal":"Am J Physiol Regul Integr Comp Physiol","authors":["Gasparini S","Stein LM","Loewen SP","Haddock CJ","Soo J","Ferguson AV","Kolar GR","Yosten GLC","Samson WK."],"DOI_URL":"https://doi.org/10.1152/ajpregu.00426.2017"},"PUB00161348":{"PMID":28844870,"ISBN":null,"volume":"96","issue":null,"year":2017,"title":"Phoenixin-14 injected intracerebroventricularly but not intraperitoneally stimulates food intake in rats.","URL":null,"raw_pages":"53-60","medline_journal":"Peptides","ISO_journal":"Peptides","authors":["Schalla M","Prinz P","Friedrich T","Scharner S","Kobelt P","Goebel-Stengel M","Rose M","Stengel A."],"DOI_URL":"https://doi.org/10.1016/j.peptides.2017.08.004"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":10,"interactions":0,"matches":807,"pathways":0,"proteins":807,"proteomes":648,"sets":0,"structural_models":{"alphafold":717},"structures":0,"taxa":2471},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":14,"alignment:full":606},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}