{"metadata":{"accession":"PF15021","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR053898","hierarchy":null,"name":{"name":"Shieldin complex subunit 1, C-terminal domain","short":"SHLD1_C"},"description":[{"text":"<p>SHLD1, also known as RINN3, is a component of the shieldin complex, a vertebrate-specific protein complex which functions as a downstream effector in the 53BP1 pathway, regulates NHEJ (non-homologous end joining) [[cite:PUB00089626],[cite:PUB00154232]]. This entry represents a conserved helical domain found at the C-terminal of SHLD1.</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00089626":{"PMID":29656893,"ISBN":null,"volume":"173","issue":"4","year":2018,"title":"DNA Repair Network Analysis Reveals Shieldin as a Key Regulator of NHEJ and PARP Inhibitor Sensitivity.","URL":null,"raw_pages":"972-988.e23","medline_journal":"Cell","ISO_journal":"Cell","authors":["Gupta R","Somyajit K","Narita T","Maskey E","Stanlie A","Kremer M","Typas D","Lammers M","Mailand N","Nussenzweig A","Lukas J","Choudhary C."],"DOI_URL":"https://doi.org/10.1016/j.cell.2018.03.050"},"PUB00154232":{"PMID":30046110,"ISBN":null,"volume":"560","issue":"7716","year":2018,"title":"53BP1 cooperation with the REV7-shieldin complex underpins DNA structure-specific NHEJ.","URL":null,"raw_pages":"122-127","medline_journal":"Nature","ISO_journal":"Nature","authors":["Ghezraoui H","Oliveira C","Becker JR","Bilham K","Moralli D","Anzilotti C","Fischer R","Deobagkar-Lele M","Sanchiz-Calvo M","Fueyo-Marcos E","Bonham S","Kessler BM","Rottenberg S","Cornall RJ","Green CM","Chapman JR."],"DOI_URL":"https://doi.org/10.1038/s41586-018-0362-1"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":3,"interactions":0,"matches":368,"pathways":0,"proteins":368,"proteomes":284,"sets":0,"structural_models":{"alphafold":327},"structures":0,"taxa":964},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":11,"alignment:full":311},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}