{"metadata":{"accession":"PF14983","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR027965","hierarchy":null,"name":{"name":"Sperm-associated microtubule inner protein 10","short":"SPMIP10-like"},"description":[{"text":"<p>This family (previously DUF4513) represents homologs of Sperm-associated microtubule inner protein 10 (SPMIP10). SPMIP10 is a microtubule inner protein (MIP) part of the axonemal dynein-decorated doublet microtubules (DMTs). It plays a role in the stabilisation of the interacting protomers of TEKTL1 - a tektin-like molecule that forms a filament in the cleft between protofilaments A11 and A12 . In the EM structure of sperm DMTs, SPMIP10 cradles the inter-TEKTL1 interface while interacting with protofilaments A11 and A12 [[cite:PUB00151496]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00151496":{"PMID":37327785,"ISBN":null,"volume":"186","issue":"13","year":2023,"title":"Structural specializations of the sperm tail.","URL":null,"raw_pages":"2880-2896.e17","medline_journal":"Cell","ISO_journal":"Cell","authors":["Leung MR","Zeng J","Wang X","Roelofs MC","Huang W","Zenezini Chiozzi R","Hevler JF","Heck AJR","Dutcher SK","Brown A","Zhang R","Zeev-Ben-Mordehai T."],"DOI_URL":"https://doi.org/10.1016/j.cell.2023.05.026"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":5,"interactions":0,"matches":333,"pathways":0,"proteins":332,"proteomes":297,"sets":0,"structural_models":{"alphafold":289},"structures":7,"taxa":1153},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":2,"alignment:full":270},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}