{"metadata":{"accession":"PF14970","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR027996","hierarchy":null,"name":{"name":"Tubulin epsilon and delta complex protein 1","short":"TEDC1"},"description":[{"text":"<p>This family represents the tubulin epsilon and delta complex protein 1 (TEDC1). This complex is required for centriole maintenance and it is a component of several ciliary structures. It acts as a positive regulator of hedgehog signalling, which play key roles in embryonic development and in cancers [[cite:PUB00094182]]. Additionally, this protein may play a role in counteracting perturbation of actin filaments, such as after treatment with the actin depolymerising microbial metabolite Chivosazole F [[cite:PUB00094181]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00094182":{"PMID":29459677,"ISBN":null,"volume":"50","issue":"3","year":2018,"title":"A CRISPR-based screen for Hedgehog signaling provides insights into ciliary function and ciliopathies.","URL":null,"raw_pages":"460-471","medline_journal":"Nat Genet","ISO_journal":"Nat. Genet.","authors":["Breslow DK","Hoogendoorn S","Kopp AR","Morgens DW","Vu BK","Kennedy MC","Han K","Li A","Hess GT","Bassik MC","Chen JK","Nachury MV."],"DOI_URL":null},"PUB00094181":{"PMID":28796488,"ISBN":null,"volume":"12","issue":"9","year":2017,"title":"Direct Interaction of Chivosazole F with Actin Elicits Cell Responses Similar to Latrunculin A but Distinct from Chondramide.","URL":null,"raw_pages":"2264-2269","medline_journal":"ACS Chem Biol","ISO_journal":"ACS Chem. Biol.","authors":["Filipuzzi I","Thomas JR","Pries V","Estoppey D","Salcius M","Studer C","Schirle M","Hoepfner D."],"DOI_URL":null}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":14,"interactions":0,"matches":1245,"pathways":0,"proteins":1191,"proteomes":831,"sets":0,"structural_models":{"alphafold":1019},"structures":0,"taxa":2779},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":27,"alignment:full":1064},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}