{"metadata":{"accession":"PF14908","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR028034","hierarchy":null,"name":{"name":"CCDC81 eukaryotic HU domain 1","short":"HU-CCDC81_euk_1"},"description":[{"text":"<p>This is the first of two HU domains found in the CCDC81-like proteins. CCDC81 has been experimentally linked to the centrosome; eukaryotic CCDC81 HU domains are predicted to function in protein-protein interactions in centrosome organization and potentially contribute to cargo-binding in conjunction with Dynein-VII. A striking lineage-specific expansion of the domain is observed in birds, where the HU domains could function in recognition of non-self molecules [[cite:PUB00091007]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00091007":{"PMID":28441108,"ISBN":null,"volume":"16","issue":"11","year":2017,"title":"Novel clades of the HU/IHF superfamily point to unexpected roles in the eukaryotic centrosome, chromosome partitioning, and biologic conflicts.","URL":null,"raw_pages":"1093-1103","medline_journal":"Cell Cycle","ISO_journal":"Cell Cycle","authors":["Burroughs AM","Kaur G","Zhang D","Aravind L."],"DOI_URL":"https://doi.org/10.1080/15384101.2017.1315494"}},"set_info":{"accession":"CL0548","name":"IHF-likeDNA-bdg"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":38,"interactions":0,"matches":1264,"pathways":0,"proteins":1262,"proteomes":801,"sets":1,"structural_models":{"alphafold":1098},"structures":9,"taxa":2643},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":30,"alignment:full":1071},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}