{"metadata":{"accession":"PF14892","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR026507","hierarchy":null,"name":{"name":"Piercer of microtubule wall 1/2","short":"PIRC1_2"},"description":[{"text":"<p>This family of proteins is found in eukaryotes and includes Piercer of microtubule wall 1/2 proteins (PIRC1/2). In mice PIRC1 expression is induced by p53 may play a role in DNA damage response and has been shown to function at the initial step of left-right asymmetry specification of the visceral organs [[cite:PUB00111186]]. PIRC1/2 are microtubule inner proteins involved in the attachment of outer dynein arms (ODAs) to dynein-decorated doublet microtubules (DMTs) in cilia axoneme [[cite:PUB00100771]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00100771":{"PMID":34715025,"ISBN":null,"volume":"184","issue":"23","year":2021,"title":"De novo identification of mammalian ciliary motility proteins using cryo-EM.","URL":null,"raw_pages":"5791-5806.e19","medline_journal":"Cell","ISO_journal":"Cell","authors":["Gui M","Farley H","Anujan P","Anderson JR","Maxwell DW","Whitchurch JB","Botsch JJ","Qiu T","Meleppattu S","Singh SK","Zhang Q","Thompson J","Lucas JS","Bingle CD","Norris DP","Roy S","Brown A."],"DOI_URL":null},"PUB00111186":{"PMID":21159655,"ISBN":null,"volume":"70","issue":"24","year":2010,"title":"Pierce1, a novel p53 target gene contributing to the ultraviolet-induced DNA damage response.","URL":null,"raw_pages":"10454-63","medline_journal":"Cancer Res","ISO_journal":"Cancer Res","authors":["Sung YH","Kim HJ","Devkota S","Roh J","Lee J","Rhee K","Bahk YY","Lee HW."],"DOI_URL":null}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":22,"interactions":0,"matches":1504,"pathways":0,"proteins":1504,"proteomes":1009,"sets":0,"structural_models":{"alphafold":1319},"structures":17,"taxa":3488},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":19,"alignment:full":1190},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}