{"metadata":{"accession":"PF14818","entry_id":null,"type":"coiled_coil","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR027882","hierarchy":null,"name":{"name":"SOGA 1/2-like, coiled-coil","short":"SOGA1-2-like_CC"},"description":[{"text":"<p>This entry represents a coiled-coil region found in microtubule cross-linking factors 1 and 2 (also known as SOGA1/2), which are members of the SOGA (suppressor of glucose by autophagy) family and in the uncharacterised human protein KIAA0408. SOGA1 regulates autophagy by playing a role in the reduction of glucose production in an adiponectin- and insulin-dependent manner [[cite:PUB00067397]]. SOGA1/2 are required for faithful chromosome segregation during mitosis [[cite:PUB00153172]]. These proteins contain long coiled-coils that dimerize and holds two N-terminal domains that bind to microtubules [[cite:PUB00153172]]. This region is found in association with [pfam:PF11365].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00067397":{"PMID":20813965,"ISBN":null,"volume":"177","issue":"4","year":2010,"title":"Adiponectin lowers glucose production by increasing SOGA.","URL":null,"raw_pages":"1936-45","medline_journal":"Am J Pathol","ISO_journal":"Am. J. Pathol.","authors":["Cowherd RB","Cowerd RB","Asmar MM","Alderman JM","Alderman EA","Garland AL","Busby WH","Bodnar WM","Rusyn I","Medoff BD","Tisch R","Mayer-Davis E","Swenberg JA","Zeisel SH","Combs TP."],"DOI_URL":"http://dx.doi.org/10.2353/ajpath.2010.100363"},"PUB00153172":{"PMID":33587225,"ISBN":null,"volume":"29","issue":"2","year":2021,"title":"SOGA1 and SOGA2/MTCL1 are CLASP-interacting proteins required for faithful chromosome segregation in human cells.","URL":null,"raw_pages":"159-173","medline_journal":"Chromosome Res","ISO_journal":"Chromosome Res","authors":["Ferreira LT","Logarinho E","Macedo JC","Maia ARR","Maiato H."],"DOI_URL":"https://doi.org/10.1007/s10577-021-09651-8"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":19,"interactions":0,"matches":2946,"pathways":0,"proteins":2945,"proteomes":745,"sets":0,"structural_models":{"alphafold":735},"structures":0,"taxa":2252},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":74,"alignment:full":2351},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}