{"metadata":{"accession":"PF14613","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR027842","hierarchy":null,"name":{"name":"HAM1-like, C-terminal domain","short":"HAM1_C"},"description":[{"text":"<p>This is a domain found at the C-terminal end of the putative cell signalling protein HAM1 from Cryptococcus neoformans and similar fungal sequences. HAM1 may act as a negative regulator of mating during vegetative growth [[cite:PUB00110896]]. Proteins with this domain often also contain an N-terminal domain [pfam:PF19343]. The member [swissprot:Q7SB48], named HAM-13, is thought to associate with MAPKs and to be required for proper cell communication but it is also possible to be involved in other processes such as cell signalling or trafficking [[cite:PUB00110895]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00155454":{"PMID":38842336,"ISBN":null,"volume":"12","issue":"7","year":2024,"title":"Phenotypic characterization of <i>HAM1</i>, a novel mating regulator of the fungal pathogen <i>Cryptococcus neoformans</i>.","URL":null,"raw_pages":"e0341923","medline_journal":"Microbiol Spectr","ISO_journal":"Microbiol Spectr","authors":["Arsenault Yee E","Ross RL","Santiago-Tirado FH."],"DOI_URL":"https://doi.org/10.1128/spectrum.03419-23"},"PUB00110896":{"PMID":25411845,"ISBN":null,"volume":"10","issue":"11","year":2014,"title":"Fungal communication requires the MAK-2 pathway elements STE-20 and RAS-2, the NRC-1 adapter STE-50 and the MAP kinase scaffold HAM-5.","URL":null,"raw_pages":"e1004762","medline_journal":"PLoS Genet","ISO_journal":"PLoS Genet","authors":["Dettmann A","Heilig Y","Valerius O","Ludwig S","Seiler S."],"DOI_URL":null},"PUB00110895":{"PMID":20473289,"ISBN":null,"volume":"28","issue":"6","year":2010,"title":"Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.","URL":null,"raw_pages":"617-623","medline_journal":"Nat Biotechnol","ISO_journal":"Nat Biotechnol","authors":["Kim DU","Hayles J","Kim D","Wood V","Park HO","Won M","Yoo HS","Duhig T","Nam M","Palmer G","Han S","Jeffery L","Baek ST","Lee H","Shim YS","Lee M","Kim L","Heo KS","Noh EJ","Lee AR","Jang YJ","Chung KS","Choi SJ","Park JY","Park Y","Kim HM","Park SK","Park HJ","Kang EJ","Kim HB","Kang HS","Park HM","Kim K","Song K","Song KB","Nurse P","Hoe KL."],"DOI_URL":null}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":29,"interactions":0,"matches":1931,"pathways":0,"proteins":1927,"proteomes":1257,"sets":0,"structural_models":{"alphafold":1593},"structures":0,"taxa":2678},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":46,"alignment:full":1603},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}