{"metadata":{"accession":"PF14534","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR027843","hierarchy":null,"name":{"name":"Domain of unknown function (DUF4440)","short":"DUF4440"},"description":[{"text":"<p>This domain is found in uncharacterised proteins from bacteria, archaea and eukaryotes, including NTF2-Like SgcJ protein from Streptomyces carzinostaticus, which plays a role in the biosynthesis of the 9-membered enediyne antitumor antibiotic C-1027. It shows a cone-like alpha+beta barrel structure with a long N-terminal alpha- helix, a curved six-stranded antiparallel beta-sheet and two additional shorter alpha-helices. Its specific function is still unkown [[cite:PUB00100883]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"<p>A <b>domain of unknown function</b> (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.</p>","thumbnail":null}],"literature":{"PUB00100883":{"PMID":27406907,"ISBN":null,"volume":"69","issue":"10","year":2016,"title":"Crystal structure of SgcJ, an NTF2-like superfamily protein involved in biosynthesis of the nine-membered enediyne antitumor antibiotic C-1027.","URL":null,"raw_pages":"731-740","medline_journal":"J Antibiot (Tokyo)","ISO_journal":"J Antibiot (Tokyo)","authors":["Huang T","Chang CY","Lohman JR","Rudolf JD","Kim Y","Chang C","Yang D","Ma M","Yan X","Crnovcic I","Bigelow L","Clancy S","Bingman CA","Yennamalli RM","Babnigg G","Joachimiak A","Phillips GN","Shen B."],"DOI_URL":null}},"set_info":{"accession":"CL0051","name":"NTF2"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":127,"interactions":0,"matches":21018,"pathways":0,"proteins":20901,"proteomes":9416,"sets":1,"structural_models":{"alphafold":13058},"structures":14,"taxa":13277},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":90,"alignment:full":10130},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":{"accession":"3b7c","name":"CRYSTAL STRUCTURE OF A NTF-2 LIKE PROTEIN OF UNKNOWN FUNCTION (SO_0125) FROM SHEWANELLA ONEIDENSIS MR-1 AT 1.70 A RESOLUTION"}}}