This entry represents a domain found in a family of membrane and transmembrane proteins from mycobacterial and related species. This domain has similarity to the ligand-binding domains of neurotransmitter ligand-gated ion channels and sensory receptors and it is likely to have similar function.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":null,"set_info":{"accession":"CL0974","name":"NLGIC_lig-bind"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":11,"interactions":0,"matches":936,"pathways":0,"proteins":936,"proteomes":500,"sets":1,"structural_models":{"alphafold":678},"structures":0,"taxa":869},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":214,"alignment:full":461},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}