{"metadata":{"accession":"PF14466","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR025219","hierarchy":null,"name":{"name":"PLAT/LH2 and C2-like Ca2+-binding lipoprotein","short":"PLCC"},"description":[{"text":"<p>A small family of bacterial proteins, found in several Bacteroides species. Structure determination (NMR and Xray) shows an immunoglobulin beta-barrel fold. Multiple homologues have been found in human gut metagenomics data sets. Structural experimentation shows it to share features with two well-established protein architectures in the SCOP database, ie, C2 (calcium/lipid-binding domain) of [pfam:PF00168] and PLAT/LH2 (lipase/lipooxigenase domain) of [pfam:PF01477]. The C2 and PLAT/LH2 domains bind Ca2+ in their functions of targeting proteins to cell-membranes; this domain is also shown to bind Ca2+ as well as to be a novel fold [[cite:PUB00075637]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00075637":{"PMID":23681886,"ISBN":null,"volume":"22","issue":"7","year":2013,"title":"Structural representative of the protein family PF14466 has a new fold and establishes links with the C2 and PLAT domains from the widely distant Pfams PF00168 and PF01477.","URL":null,"raw_pages":"1000-7","medline_journal":"Protein Sci","ISO_journal":"Protein Sci.","authors":["Serrano P","Geralt M","Mohanty B","Wuthrich K."],"DOI_URL":"http://dx.doi.org/10.1002/pro.2284"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":1,"interactions":0,"matches":58,"pathways":0,"proteins":58,"proteomes":52,"sets":0,"structural_models":{"alphafold":39},"structures":2,"taxa":112},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":2,"alignment:full":16},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}