{"metadata":{"accession":"PF14377","entry_id":null,"type":"conserved_site","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR025527","hierarchy":null,"name":{"name":"Ubiquitin binding region","short":"UBM"},"description":[{"text":"<p>This family contains repetitive element (RE) from a subgroup of HECT E3 ubiquitin ligases and the Y-family translesion polymerases, including human HUWE1 and Arabidopsis UPL1. Each of these repetitive elements are approximately 20 amino acids in length and contain two predicted helical segments separated by a Leu-Pro motif. The REs from the Y-family polymerases were shown to bind ubiquitin and were the basis for a novel ubiquitin-binding domain called the ubiquitin-binding motif (UBM) [[cite:PUB00091009]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00091009":{"PMID":26658142,"ISBN":null,"volume":"37","issue":null,"year":2016,"title":"The UVS9 gene of Chlamydomonas encodes an XPG homolog with a new conserved domain.","URL":null,"raw_pages":"33-42","medline_journal":"DNA Repair (Amst)","ISO_journal":"DNA Repair (Amst.)","authors":["Deitsch E","Hibbard EM","Petersen JL."],"DOI_URL":"https://doi.org/10.1016/j.dnarep.2015.11.003"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":363,"interactions":0,"matches":22640,"pathways":0,"proteins":8833,"proteomes":3156,"sets":0,"structural_models":{"alphafold":2922},"structures":23,"taxa":8298},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":163,"alignment:full":16812},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}