This presumed domain is found in a group of uncharacterised prokaryotic proteins. Proteins in this group are thought to mediate flavinylation-associated electron transfer in the cytoplasmic membrane and constitute a novel class of cytochromes. There are two conserved histidines in this domain, which are predicted to bind to two haem cofactors [[cite:PUB00160945]].
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":{"PUB00160945":{"PMID":39041811,"ISBN":null,"volume":"9","issue":"8","year":2024,"title":"Versatile roles of protein flavinylation in bacterial extracyotosolic electron transfer.","URL":null,"raw_pages":"e0037524","medline_journal":"mSystems","ISO_journal":"mSystems","authors":["Huang S","Meheust R","Barquera B","Light SH."],"DOI_URL":"https://doi.org/10.1128/msystems.00375-24"}},"set_info":{"accession":"CL0328","name":"2heme_cytochrom"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":10,"interactions":0,"matches":1335,"pathways":0,"proteins":1330,"proteomes":1115,"sets":1,"structural_models":{"alphafold":964},"structures":0,"taxa":2418},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":90,"alignment:full":738},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}