{"metadata":{"accession":"PF14336","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR025504","hierarchy":null,"name":{"name":"D-glutamate cyclase-like, C-terminal","short":"GLUCM-like_C"},"description":[{"text":"<p>This entry represents the C-terminal domain of mitochondrial D-glutamate cyclase, which converts D-glutamate to 5-oxo-D-proline [[cite:PUB00086027]]. This is a conserved domain also found in uncharacterised proteins from bacteria and archaea. Structural studies of the hypothetical protein TON_0340 from Thermococcus onnurineus revealed an active-site cavity harbouring a metal-binding site containing six invariant aspartate and glutamate residues that adopts an alpha/beta-structure [[cite:PUB00151593]]. Biochemical and mutational analysis show that TON_0340 is a Mn+2-dependent phosphatase [[cite:PUB00151593]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00151593":{"PMID":27907125,"ISBN":null,"volume":"11","issue":"12","year":2016,"title":"Identification of a Highly Conserved Hypothetical Protein TON_0340 as a Probable Manganese-Dependent Phosphatase.","URL":null,"raw_pages":"e0167549","medline_journal":"PLoS One","ISO_journal":"PLoS One","authors":["Sohn YS","Lee SG","Lee KH","Ku B","Shin HC","Cha SS","Kim YG","Lee HS","Kang SG","Oh BH."],"DOI_URL":null},"PUB00086027":{"PMID":28266638,"ISBN":null,"volume":"7","issue":null,"year":2017,"title":"D-Glutamate is metabolized in the heart mitochondria.","URL":null,"raw_pages":"43911","medline_journal":"Sci Rep","ISO_journal":"Sci Rep","authors":["Ariyoshi M","Katane M","Hamase K","Miyoshi Y","Nakane M","Hoshino A","Okawa Y","Mita Y","Kaimoto S","Uchihashi M","Fukai K","Ono K","Tateishi S","Hato D","Yamanaka R","Honda S","Fushimura Y","Iwai-Kanai E","Ishihara N","Mita M","Homma H","Matoba S."],"DOI_URL":"https://doi.org/10.1038/srep43911"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":16,"interactions":0,"matches":1931,"pathways":0,"proteins":1872,"proteomes":1349,"sets":0,"structural_models":{"alphafold":1483},"structures":6,"taxa":3617},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":34,"alignment:full":1373},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}