This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 137 and 164 amino acids in length. These proteins are integral membrane proteins with four transmembrane helices. The contain several conserved histidines and AlphaFold 3 predicts a confident zinc binding site. Structure prediction also suggests that these proteins might form a homotetrameric complex UniProt:A0A3B9LPY9 iPTM=0.9. The four subunits are alternating in different orientations in the presumed membrane. The structure prediction also suggests a central pore between the subunits.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":null,"set_info":{"accession":"CL0131","name":"DoxD-like"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":5,"interactions":0,"matches":3778,"pathways":0,"proteins":3778,"proteomes":2396,"sets":1,"structural_models":{"alphafold":2153},"structures":0,"taxa":3221},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":69,"alignment:full":1762},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}