{"metadata":{"accession":"PF14267","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR025579","hierarchy":null,"name":{"name":"Domain of unknown function (DUF4357)","short":"DUF4357"},"description":[{"text":"<p>This domain family is found in bacteria and archaea, and is approximately 100 amino acids in length. Shows sequence similarity to the RAMA domain [pfam:PF18755] which suggests this may be a DNA-binding domain.</p>","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"<p>A <b>domain of unknown function</b> (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.</p>","thumbnail":null}],"literature":null,"set_info":{"accession":"CL0831","name":"SAND"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":40,"interactions":0,"matches":1806,"pathways":0,"proteins":1796,"proteomes":1689,"sets":1,"structural_models":{"alphafold":1135},"structures":0,"taxa":3238},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":35,"alignment:full":972},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}