This domain family is found in bacteria, archaea, and is approximately 170 to 200 amino acids in length. This domain is part of the glutaminase superfamily, suggesting it may have an enzymatic function. The domain is founded between two transmembrane helix domains giving it a membrane localisation.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":null,"set_info":{"accession":"CL0014","name":"Glutaminase_I"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":42,"interactions":0,"matches":5708,"pathways":0,"proteins":5702,"proteomes":5273,"sets":1,"structural_models":{"alphafold":3498},"structures":0,"taxa":7409},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":66,"alignment:full":2760},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}