{"metadata":{"accession":"PF14251","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR025595","hierarchy":null,"name":{"name":"PterinBD-DUF4346","short":"PterinBD-DUF4346"},"description":[{"text":"<p>This domain is found in bacteria, archaea and a few lower eukaryotes species. There are two conserved sequence motifs: LDP and DHA. Many members of this family have been annotated as dihydropteroate synthases, however no experimental evidence can be found for this and [swissprot:Q57571] has been shown not to possess dihydropteroate synthase activity [[cite:PUB00057368]]. In bacteria, this domain is found in predicted conflict systems that also encode genes for an active Thymidylate synthase and a pterin-dependent one-carbon carrier (MtrA domain). This system is predicted to deplete virally generated nucleotides and replace them with a nucleotide that restricts invasive DNA or protects host DNA [[cite:PUB00155486]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00155486":{"PMID":37889040,"ISBN":null,"volume":"51","issue":"21","year":2023,"title":"Functionally comparable but evolutionarily distinct nucleotide-targeting effectors help identify conserved paradigms across diverse immune systems.","URL":null,"raw_pages":"11479-11503","medline_journal":"Nucleic Acids Res","ISO_journal":"Nucleic Acids Res","authors":["Nicastro GG","Burroughs AM","Iyer LM","Aravind L."],"DOI_URL":"https://doi.org/10.1093/nar/gkad879"},"PUB00057368":{"PMID":10426953,"ISBN":null,"volume":"6","issue":"8","year":1999,"title":"Identifying two ancient enzymes in Archaea using predicted secondary structure alignment.","URL":null,"raw_pages":"750-4","medline_journal":"Nat Struct Biol","ISO_journal":"Nat. Struct. Biol.","authors":["Xu H","Aurora R","Rose GD","White RH."],"DOI_URL":"http://dx.doi.org/10.1038/11525"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":16,"interactions":0,"matches":781,"pathways":0,"proteins":775,"proteomes":668,"sets":0,"structural_models":{"alphafold":574},"structures":0,"taxa":1712},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":65,"alignment:full":503},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}