{"metadata":{"accession":"PF14243","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR025643","hierarchy":null,"name":{"name":"ATP-grasp domain, R2K clade family 3","short":"R2K_3"},"description":[{"text":"<p>Family of ATP-grasp enzymes belonging to the R2K clade, wherein one of the absolutely-conserved lysine residues has migrated to the RAGYNA domain which is a part of the core ATP-grasp module. This family is predicted to catalyze peptide ligation reactions on protein substrates in biological conflict contexts, probably between bacteriophages and their hosts [[cite:PUB00091030]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00091030":{"PMID":25976611,"ISBN":null,"volume":"10","issue":null,"year":2015,"title":"The eukaryotic translation initiation regulator CDC123 defines a divergent clade of ATP-grasp enzymes with a predicted role in novel protein modifications.","URL":null,"raw_pages":"21","medline_journal":"Biol Direct","ISO_journal":"Biol. Direct","authors":["Burroughs AM","Zhang D","Aravind L."],"DOI_URL":"https://doi.org/10.1186/s13062-015-0053-x"}},"set_info":{"accession":"CL0179","name":"ATP-grasp"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":6,"interactions":0,"matches":1190,"pathways":0,"proteins":1184,"proteomes":1071,"sets":1,"structural_models":{"alphafold":664},"structures":0,"taxa":1851},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":33,"alignment:full":507},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}