{"metadata":{"accession":"PF14237","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR025640","hierarchy":null,"name":{"name":"GYF domain 2","short":"GYF_2"},"description":[{"text":"<p>This domain is found in bacteria, archaea and eukaryotes, and is approximately 50 amino acids in length. It contains an evolutionary conserved signature W-X-Y-X6-11-GPF-X4-M-X2-W-X3-GYF, the site of interaction with proline-rich peptides. Family members include RME-8 (Required for receptor-mediated endocytosis 8), a DNAJC13 protein. RME-8 was first identified as a protein that is required for endocytosis in Caenorhabditis elegans. It coordinates the activity of the WASH complex with the function of the retromer SNX dimer to control endosomal tubulation [[cite:PUB00091010]]. Family members found in Arabidopsis include Arabidopsis trithorax-related3 (Atxr3), also known as set domain group 2 (Sdg2). It is the major enzyme responsible for H3K4me3 in Arabidopsis and SDG2-dependent H3K4m3 is critical for regulating gene expression and plant development [[cite:PUB00085381]]. Another family member found in Arabidopsis is Tic56. It is an essential subunit of a 1-MDa protein complex at the inner chloroplast envelope membrane [[cite:PUB00091011]]. Furthermore, Tic56 is important for rRNA processing and chloroplast ribosome assembly [[cite:PUB00091012]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00091011":{"PMID":28125316,"ISBN":null,"volume":"12","issue":"3","year":2017,"title":"Protein import-independent functions of Tic56, a component of the 1-MDa translocase at the inner chloroplast envelope membrane.","URL":null,"raw_pages":"e1284726","medline_journal":"Plant Signal Behav","ISO_journal":"Plant Signal Behav","authors":["Agne B","Kohler D","Baginsky S."],"DOI_URL":"https://doi.org/10.1080/15592324.2017.1284726"},"PUB00091012":{"PMID":27733515,"ISBN":null,"volume":"172","issue":"4","year":2016,"title":"Importance of Translocon Subunit Tic56 for rRNA Processing and Chloroplast Ribosome Assembly.","URL":null,"raw_pages":"2429-2444","medline_journal":"Plant Physiol","ISO_journal":"Plant Physiol.","authors":["Kohler D","Helm S","Agne B","Baginsky S."],"DOI_URL":"https://doi.org/10.1104/pp.16.01393"},"PUB00091010":{"PMID":24643499,"ISBN":null,"volume":"127","issue":"Pt 9","year":2014,"title":"RME-8 coordinates the activity of the WASH complex with the function of the retromer SNX dimer to control endosomal tubulation.","URL":null,"raw_pages":"2053-70","medline_journal":"J Cell Sci","ISO_journal":"J. Cell. Sci.","authors":["Freeman CL","Hesketh G","Seaman MN."],"DOI_URL":"https://doi.org/10.1242/jcs.144659"},"PUB00085381":{"PMID":20937886,"ISBN":null,"volume":"107","issue":"43","year":2010,"title":"SET DOMAIN GROUP2 is the major histone H3 lysine [corrected] 4 trimethyltransferase in Arabidopsis.","URL":null,"raw_pages":"18557-62","medline_journal":"Proc Natl Acad Sci U S A","ISO_journal":"Proc. Natl. Acad. Sci. U.S.A.","authors":["Guo L","Yu Y","Law JA","Zhang X."],"DOI_URL":"https://doi.org/10.1073/pnas.1010478107"}},"set_info":{"accession":"CL0673","name":"GYF"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":191,"interactions":0,"matches":8373,"pathways":0,"proteins":8264,"proteomes":4666,"sets":1,"structural_models":{"alphafold":4115},"structures":4,"taxa":9912},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":238,"alignment:full":5211},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}