{"metadata":{"accession":"PF14159","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR025564","hierarchy":null,"name":{"name":"CAAD domains of cyanobacterial aminoacyl-tRNA synthetase","short":"CAAD"},"description":[{"text":"<p>This domain is present in aminoacyl-tRNA synthetases (aaRSs), enzymes that couple tRNAs to their cognate amino acids [[cite:PUB00066703]]. aaRSs from cyanobacteria containing the CAAD (for cyanobacterial aminoacyl-tRNA synthetases appended domain) protein domains are localised in the thylakoid membrane. The domain bears two putative transmembrane helices and is present in glutamyl-, isoleucyl-, leucyl-, and valyl-tRNA synthetases, the latter of which has probably recruited the domain more than once during evolution.</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00066703":{"PMID":18775898,"ISBN":null,"volume":"25","issue":"11","year":2008,"title":"Intraphylum diversity and complex evolution of cyanobacterial aminoacyl-tRNA synthetases.","URL":null,"raw_pages":"2369-89","medline_journal":"Mol Biol Evol","ISO_journal":"Mol. Biol. Evol.","authors":["Luque I","Riera-Alberola ML","Andujar A","Ochoa de Alda JA."],"DOI_URL":"http://dx.doi.org/10.1093/molbev/msn197"},"PUB00152396":{"PMID":21965654,"ISBN":null,"volume":"286","issue":"47","year":2011,"title":"Membrane anchoring of aminoacyl-tRNA synthetases by convergent acquisition of a novel protein domain.","URL":null,"raw_pages":"41057-68","medline_journal":"J Biol Chem","ISO_journal":"J Biol Chem","authors":["Olmedo-Verd E","Santamaria-Gomez J","Ochoa de Alda JA","Ribas de Pouplana L","Luque I."],"DOI_URL":"https://doi.org/10.1074/jbc.M111.242461"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":68,"interactions":0,"matches":3553,"pathways":0,"proteins":3537,"proteomes":674,"sets":0,"structural_models":{"alphafold":2760},"structures":0,"taxa":1866},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":93,"alignment:full":2342},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}