This family of bacterial proteins includes SPy_2034 from Streptococcus pyogenes, which is though to play an important role in the virulence of the bacteria. This protein shows a unique tetrameric organisation composed of four helix-loop- helix motifs [[cite:PUB00101005]].
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":{"PUB00101005":{"PMID":24825900,"ISBN":null,"volume":"289","issue":"26","year":2014,"title":"Functional and structural properties of a novel protein and virulence factor (Protein sHIP) in Streptococcus pyogenes.","URL":null,"raw_pages":"18175-88","medline_journal":"J Biol Chem","ISO_journal":"J Biol Chem","authors":["Wisniewska M","Happonen L","Kahn F","Varjosalo M","Malmstrom L","Rosenberger G","Karlsson C","Cazzamali G","Pozdnyakova I","Frick IM","Bjorck L","Streicher W","Malmstrom J","Wikstrom M."],"DOI_URL":null}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":4,"interactions":0,"matches":436,"pathways":0,"proteins":436,"proteomes":414,"sets":0,"structural_models":{"alphafold":321},"structures":2,"taxa":771},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":14,"alignment:full":239},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":{"accession":"4pz1","name":"Crystal structure of a sHIP (UniProt Id: Q99XU0) mutant from Streptococcus pyogenes"}}}