{"metadata":{"accession":"PF14112","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR025560","hierarchy":null,"name":{"name":"Immunity protein 22","short":"DUF4284"},"description":[{"text":"<p>A predicted immunity protein with an alpha+beta fold and conserved  tryptophan,tyrosine and an acidic residues. Proteins containing this domain are present in bacterial polymorphic toxin systems as an  immediate gene  neighbor of the toxin gene, which usually contains  toxin domains of the  ColD/E5, Tox-REase-4, Ntox49 or Ntox14  families [[cite:PUB00066726]]. The domain is also found in heterogeneous  polyimmunity loci.</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00066726":{"PMID":22731697,"ISBN":null,"volume":"7","issue":null,"year":2012,"title":"Polymorphic toxin systems: Comprehensive characterization of trafficking modes, processing, mechanisms of action, immunity and ecology using comparative genomics.","URL":null,"raw_pages":"18","medline_journal":"Biol Direct","ISO_journal":"Biol. Direct","authors":["Zhang D","de Souza RF","Anantharaman V","Iyer LM","Aravind L."],"DOI_URL":"http://dx.doi.org/10.1186/1745-6150-7-18"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":5,"interactions":0,"matches":564,"pathways":0,"proteins":558,"proteomes":502,"sets":0,"structural_models":{"alphafold":333},"structures":0,"taxa":869},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":7,"alignment:full":184},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}