{"metadata":{"accession":"PF14082","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR025359","hierarchy":null,"name":{"name":"Shedu protein SduA, C-terminal","short":"SduA_C"},"description":[{"text":"<p>This domain is found mostly in bacteria. It is found at the C-terminal of Shedu protein SduA, the only component of antiviral defense system Shedu. Expression of Shedu in B.subtilis (strain BEST7003) confers resistance to phages phi105, phi29, rho14 and to a lesser extent to SPP1 [[cite:PUB00097806]]. This domain may have endonuclease activity [[cite:PUB00066699]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00066699":{"PMID":22638584,"ISBN":null,"volume":"40","issue":"15","year":2012,"title":"Sequence, structure and functional diversity of PD-(D/E)XK phosphodiesterase superfamily.","URL":null,"raw_pages":"7016-45","medline_journal":"Nucleic Acids Res","ISO_journal":"Nucleic Acids Res.","authors":["Steczkiewicz K","Muszewska A","Knizewski L","Rychlewski L","Ginalski K."],"DOI_URL":"http://dx.doi.org/10.1093/nar/gks382"},"PUB00097806":{"PMID":29371424,"ISBN":null,"volume":"359","issue":"6379","year":2018,"title":"Systematic discovery of antiphage defense systems in the microbial pangenome.","URL":null,"raw_pages":null,"medline_journal":"Science","ISO_journal":"Science","authors":["Doron S","Melamed S","Ofir G","Leavitt A","Lopatina A","Keren M","Amitai G","Sorek R."],"DOI_URL":null}},"set_info":{"accession":"CL0236","name":"PDDEXK"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":18,"interactions":0,"matches":1304,"pathways":0,"proteins":1304,"proteomes":1214,"sets":1,"structural_models":{"alphafold":753},"structures":5,"taxa":2464},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":26,"alignment:full":528},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}