{"metadata":{"accession":"PF14026","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR025336","hierarchy":null,"name":{"name":"Nickel responsive protein SCO4226-like","short":"SCO4226-like"},"description":[{"text":"<p>This family of proteins is found in prokaryotes, including the nickel responsive protein SCO4226 from Streptomyces coelicolor ([swissprot:Q9FCE4]). SCO4226 adopts a dimeric configuration able to bind four nickel ions, with each monomer showing a typical ferredoxin-like fold with five beta-strands packing against two alpha-helices. It seems to play a role in cellular nickel homeostasis, detoxification, and/or nickel utilization in specialised cytoplasmic compartment [[cite:PUB00093075]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00093075":{"PMID":25285530,"ISBN":null,"volume":"9","issue":"10","year":2014,"title":"Streptomyces coelicolor SCO4226 is a nickel binding protein.","URL":null,"raw_pages":"e109660","medline_journal":"PLoS One","ISO_journal":"PLoS ONE","authors":["Lu M","Jiang YL","Wang S","Jin H","Zhang RG","Virolle MJ","Chen Y","Zhou CZ."],"DOI_URL":null}},"set_info":{"accession":"CL0032","name":"Dim_A_B_barrel"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":13,"interactions":0,"matches":3085,"pathways":0,"proteins":3059,"proteomes":2553,"sets":1,"structural_models":{"alphafold":1873},"structures":2,"taxa":3944},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":68,"alignment:full":1590},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":{"accession":"4oi3","name":"Crystal structure analysis of SCO4226 from Streptomyces coelicolor A3(2)"}}}