{"metadata":{"accession":"PF13959","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR025313","hierarchy":null,"name":{"name":"ATP-dependent rRNA helicase SPB4-like, C-terminal extension","short":"CTE_SPB4"},"description":[{"text":"<p>This short domain is found at the C-terminus of many helicase proteins, including ATP-dependent rRNA helicase SPB4 from Saccharomyces cerevisiae, which is involved in the biogenesis of 60S ribosomal subunits. SPB4 is organised into four domains: dual RecA domains ([pfam:PF00270] and [pfam:PF00271]), a C-terminal extension (CTE, represented by this entry) and a C-terminal tail ([pfam:PF23681]). This domain packs closely onto the catalytic core and engages the four nucleotides immediately 5' to those within the RNA binding pocket. It shows a mainly alpha- helical structure [[cite:PUB00153742]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00153742":{"PMID":36482249,"ISBN":null,"volume":"29","issue":"12","year":2022,"title":"Sequence-specific remodeling of a topologically complex RNP substrate by Spb4.","URL":null,"raw_pages":"1228-1238","medline_journal":"Nat Struct Mol Biol","ISO_journal":"Nat Struct Mol Biol","authors":["Cruz VE","Sekulski K","Peddada N","Sailer C","Balasubramanian S","Weirich CS","Stengel F","Erzberger JP."],"DOI_URL":"https://doi.org/10.1038/s41594-022-00874-9"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":216,"interactions":0,"matches":15992,"pathways":0,"proteins":15982,"proteomes":3488,"sets":0,"structural_models":{"alphafold":13653},"structures":50,"taxa":9181},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":343,"alignment:full":12172},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}