This short domain is found in fungi, plants and animals, and the proteins appear to be necessary for chromosome segregation during meiosis.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":{"PUB00044235":{"PMID":16169489,"ISBN":null,"volume":"15","issue":"18","year":2005,"title":"Novel genes required for meiotic chromosome segregation are identified by a high-throughput knockout screen in fission yeast.","URL":null,"raw_pages":"1663-9","medline_journal":"Curr Biol","ISO_journal":"Curr. Biol.","authors":["Gregan J","Rabitsch PK","Sakem B","Csutak O","Latypov V","Lehmann E","Kohli J","Nasmyth K."],"DOI_URL":"http://dx.doi.org/10.1016/j.cub.2005.07.059"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":39,"interactions":0,"matches":3979,"pathways":0,"proteins":3976,"proteomes":2444,"sets":0,"structural_models":{"alphafold":3265},"structures":0,"taxa":6680},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":27,"alignment:full":3016},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}