{"metadata":{"accession":"PF13910","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR025209","hierarchy":null,"name":{"name":"EMARD, N-terminal domain","short":"EMARD_N"},"description":[{"text":"<p>This entry represents the KEN domain found at the N-terminal of Endoplasmic reticulum membrane-associated RNA degradation protein (EMARD, also known as C6orf70 in human), which belongs to the HEPN superfamily. It carries the characteristic, highly conserved RxxxxHG sequence motif [[cite:PUB00091124]]. This domain may be a RNase that is involved in the degradation of rRNAs, mRNAs associated with the endoplasmic reticulum membrane. EMARD may play a role in neuronal migration during embryonic development [[cite:PUB00089893]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00089893":{"PMID":24056535,"ISBN":null,"volume":"136","issue":"Pt 11","year":2013,"title":"Periventricular heterotopia in 6q terminal deletion syndrome: role of the C6orf70 gene.","URL":null,"raw_pages":"3378-94","medline_journal":"Brain","ISO_journal":"Brain","authors":["Conti V","Carabalona A","Pallesi-Pocachard E","Parrini E","Leventer RJ","Buhler E","McGillivray G","Michel FJ","Striano P","Mei D","Watrin F","Lise S","Pagnamenta AT","Taylor JC","Kini U","Clayton-Smith J","Novara F","Zuffardi O","Dobyns WB","Scheffer IE","Robertson SP","Berkovic SF","Represa A","Keays DA","Cardoso C","Guerrini R."],"DOI_URL":"https://doi.org/10.1093/brain/awt249"},"PUB00091124":{"PMID":23768067,"ISBN":null,"volume":"8","issue":null,"year":2013,"title":"Comprehensive analysis of the HEPN superfamily: identification of novel roles in intra-genomic conflicts, defense, pathogenesis and RNA processing.","URL":null,"raw_pages":"15","medline_journal":"Biol Direct","ISO_journal":"Biol. Direct","authors":["Anantharaman V","Makarova KS","Burroughs AM","Koonin EV","Aravind L."],"DOI_URL":"https://doi.org/10.1186/1745-6150-8-15"}},"set_info":{"accession":"CL0291","name":"KNTase_C"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":24,"interactions":0,"matches":1523,"pathways":0,"proteins":1409,"proteomes":793,"sets":1,"structural_models":{"alphafold":1213},"structures":0,"taxa":2656},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":8,"alignment:full":1309},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}