{"metadata":{"accession":"PF13827","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR025240","hierarchy":null,"name":{"name":"Domain of unknown function (DUF4189)","short":"DUF4189"},"description":[{"text":"<p>This domain of unknown function contains six well-conserved cysteine residues.</p>","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"<p>A <b>domain of unknown function</b> (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.</p>","thumbnail":null}],"literature":null,"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":22,"interactions":0,"matches":2152,"pathways":0,"proteins":2037,"proteomes":1117,"sets":0,"structural_models":{"alphafold":1227},"structures":1,"taxa":1768},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":41,"alignment:full":887},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}