{"metadata":{"accession":"PF13826","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR025444","hierarchy":null,"name":{"name":"Monooxygenase af470-like","short":"Monooxy_af470-like"},"description":[{"text":"<p>This entry includes Monooxygenase af470-like from Aspergillus fumigatus, which is part of the fma gene cluster that mediates the biosynthesis of fumagillin, a meroterpenoid with numerous biological activities [[cite:PUB00081410]]. It has been suggested that af470 mediates the oxidative cleavage of the terminal alkene of the dodecapentaenoate side chain into the carboxylic acid present in fumagillin [[cite:PUB00081411]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00081410":{"PMID":23488861,"ISBN":null,"volume":"135","issue":"12","year":2013,"title":"The fumagillin biosynthetic gene cluster in Aspergillus fumigatus encodes a cryptic terpene cyclase involved in the formation of β-trans-bergamotene.","URL":null,"raw_pages":"4616-9","medline_journal":"J Am Chem Soc","ISO_journal":"J. Am. Chem. Soc.","authors":["Lin HC","Chooi YH","Dhingra S","Xu W","Calvo AM","Tang Y."],"DOI_URL":"http://dx.doi.org/10.1021/ja312503y"},"PUB00081411":{"PMID":24568283,"ISBN":null,"volume":"136","issue":"11","year":2014,"title":"Generation of complexity in fungal terpene biosynthesis: discovery of a multifunctional cytochrome P450 in the fumagillin pathway.","URL":null,"raw_pages":"4426-36","medline_journal":"J Am Chem Soc","ISO_journal":"J. Am. Chem. Soc.","authors":["Lin HC","Tsunematsu Y","Dhingra S","Xu W","Fukutomi M","Chooi YH","Cane DE","Calvo AM","Watanabe K","Tang Y."],"DOI_URL":"http://dx.doi.org/10.1021/ja500881e"}},"set_info":{"accession":"CL0032","name":"Dim_A_B_barrel"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":20,"interactions":0,"matches":2846,"pathways":0,"proteins":2841,"proteomes":2518,"sets":1,"structural_models":{"alphafold":1872},"structures":0,"taxa":4153},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":30,"alignment:full":1674},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}