This domain of unknown function is found in a putative tumour suppressor gene [[cite:PUB00057318]] and in a ligand for the the urokinase-type plasminogen activator receptor, which plays a role in cellular migration and adhesion [[cite:PUB00057319],[cite:PUB00057320]].
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":{"PUB00057320":{"PMID":19667118,"ISBN":null,"volume":"23","issue":"12","year":2009,"title":"Sushi repeat protein X-linked 2, a novel mediator of angiogenesis.","URL":null,"raw_pages":"4105-16","medline_journal":"FASEB J","ISO_journal":"FASEB J.","authors":["Miljkovic-Licina M","Hammel P","Garrido-Urbani S","Bradfield PF","Szepetowski P","Imhof BA."],"DOI_URL":null},"PUB00057319":{"PMID":18718938,"ISBN":null,"volume":"17","issue":"23","year":2008,"title":"Epileptic and developmental disorders of the speech cortex: ligand/receptor interaction of wild-type and mutant SRPX2 with the plasminogen activator receptor uPAR.","URL":null,"raw_pages":"3617-30","medline_journal":"Hum Mol Genet","ISO_journal":"Hum. Mol. Genet.","authors":["Royer-Zemmour B","Ponsole-Lenfant M","Gara H","Roll P","Leveque C","Massacrier A","Ferracci G","Cillario J","Robaglia-Schlupp A","Vincentelli R","Cau P","Szepetowski P."],"DOI_URL":"http://dx.doi.org/10.1093/hmg/ddn256"},"PUB00057318":{"PMID":15563452,"ISBN":null,"volume":"280","issue":"9","year":2005,"title":"DRO1, a gene down-regulated by oncogenes, mediates growth inhibition in colon and pancreatic cancer cells.","URL":null,"raw_pages":"7962-75","medline_journal":"J Biol Chem","ISO_journal":"J. Biol. Chem.","authors":["Bommer GT","Jager C","Durr EM","Baehs S","Eichhorst ST","Brabletz T","Hu G","Frohlich T","Arnold G","Kress DC","Goke B","Fearon ER","Kolligs FT."],"DOI_URL":"http://dx.doi.org/10.1074/jbc.M412593200"}},"set_info":{"accession":"CL0172","name":"Thioredoxin"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":38,"interactions":0,"matches":7353,"pathways":0,"proteins":5184,"proteomes":2744,"sets":1,"structural_models":{"alphafold":4088},"structures":0,"taxa":5180},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":60,"alignment:full":5281},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}