{"metadata":{"accession":"PF13689","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR025293","hierarchy":null,"name":{"name":"YfiR/HmsC-like","short":"DUF4154"},"description":[{"text":"<p>This family of proteins is found in bacteria and includes YfiR from E. coli. YfiR has been shown to regulate YfiN, a diguanylate cyclase and a bifunctional protein that produces c-di-GMP in response to reductive stress and then dynamically relocates to the division site to arrest cell division in response to envelope stress in Escherichia coli. YfiR may serve as a periplasmic redox sensor that regulates YfiN activity in response to reducing conditions [[cite:PUB00088310],[cite:PUB00088309]]. HmsC in Yersinia Pestis is the orthologue of YfiR from E. coli [[cite:PUB00091013]]. HmsC is a periplasmic protein that interacts directly with the periplasmic domain (PD) of HmsD and causes proteolytic degradation of HmsD, which in turn negatively regulates Y. pestis biofilm formation [[cite:PUB00091014]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00088309":{"PMID":27507823,"ISBN":null,"volume":"7","issue":"4","year":2016,"title":"A Diguanylate Cyclase Acts as a Cell Division Inhibitor in a Two-Step Response to Reductive and Envelope Stresses.","URL":null,"raw_pages":null,"medline_journal":"MBio","ISO_journal":"MBio","authors":["Kim HK","Harshey RM."],"DOI_URL":"https://doi.org/10.1128/mBio.00822-16"},"PUB00088310":{"PMID":25849887,"ISBN":null,"volume":"461","issue":"1","year":2015,"title":"Crystal structures of YfiR from Pseudomonas aeruginosa in two redox states.","URL":null,"raw_pages":"14-20","medline_journal":"Biochem Biophys Res Commun","ISO_journal":"Biochem. Biophys. Res. Commun.","authors":["Yang X","Yang XA","Xu M","Zhou L","Fan Z","Jiang T."],"DOI_URL":"https://doi.org/10.1016/j.bbrc.2015.03.160"},"PUB00091013":{"PMID":25586342,"ISBN":null,"volume":"17","issue":"4","year":2015,"title":"The Yersinia pestis HmsCDE regulatory system is essential for blockage of the oriental rat flea (Xenopsylla cheopis), a classic plague vector.","URL":null,"raw_pages":"947-59","medline_journal":"Environ Microbiol","ISO_journal":"Environ. Microbiol.","authors":["Bobrov AG","Kirillina O","Vadyvaloo V","Koestler BJ","Hinz AK","Mack D","Waters CM","Perry RD."],"DOI_URL":"https://doi.org/10.1111/1462-2920.12419"},"PUB00091014":{"PMID":24192006,"ISBN":null,"volume":"16","issue":"4","year":2014,"title":"HmsC, a periplasmic protein, controls biofilm formation via repression of HmsD, a diguanylate cyclase in Yersinia pestis.","URL":null,"raw_pages":"1202-16","medline_journal":"Environ Microbiol","ISO_journal":"Environ. Microbiol.","authors":["Ren GX","Yan HQ","Zhu H","Guo XP","Sun YC."],"DOI_URL":"https://doi.org/10.1111/1462-2920.12323"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":17,"interactions":0,"matches":2788,"pathways":0,"proteins":2780,"proteomes":1988,"sets":0,"structural_models":{"alphafold":1729},"structures":12,"taxa":3030},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":98,"alignment:full":1365},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":{"accession":"5eb1","name":"the YfiB-YfiR complex"}}}