This domain is found at the N-terminal of bacterial toxin systems, including Tse7 (type IV secretion exported 7) from Pseudomonas aeruginosa, a type VI secretion exported toxin with DNase activity that induces growth arrest and ultimately DNA degradation within target cell [[cite:PUB00098743]]. The structure of this domain has a PAAR-like organisation necessary for interaction with T6SS VgrG tip and correct toxin delivery [[cite:PUB00098743],[cite:PUB00098744]].
","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00098743":{"PMID":30455305,"ISBN":null,"volume":"115","issue":"49","year":2018,"title":"The Pseudomonas aeruginosa T6SS-VgrG1b spike is topped by a PAAR protein eliciting DNA damage to bacterial competitors.","URL":null,"raw_pages":"12519-12524","medline_journal":"Proc Natl Acad Sci U S A","ISO_journal":"Proc Natl Acad Sci U S A","authors":["Pissaridou P","Allsopp LP","Wettstadt S","Howard SA","Mavridou DAI","Filloux A."],"DOI_URL":null},"PUB00098744":{"PMID":31993035,"ISBN":null,"volume":"10","issue":null,"year":2019,"title":"Redundancy and Specificity of Type VI Secretion vgrG Loci in Antibacterial Activity of Agrobacterium tumefaciens 1D1609 Strain.","URL":null,"raw_pages":"3004","medline_journal":"Front Microbiol","ISO_journal":"Front Microbiol","authors":["Santos MNM","Cho ST","Wu CF","Chang CJ","Kuo CH","Lai EM."],"DOI_URL":null}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":93,"interactions":0,"matches":1800,"pathways":0,"proteins":1800,"proteomes":1029,"sets":0,"structural_models":{"alphafold":1061},"structures":1,"taxa":1707},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":53,"alignment:full":721},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}